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Common plecos and oscars produce a lot of waste so that could be a contibuting factor to the problem. This waste in turn releases ammonia and other chemicals which can help festering bacteria within the tank. To me it seems like a fungal infection but clean out the tank every few days and find some medicines, Tetra makes some superb ones.
I do around 70% on my nano tanks a week and they are usually fine, although generally its recomended to change the frequency and amount with the size of tank and the fish present. With a common pleco and and oscar try to do twice a week and around 50%. Make sure the tank isn't cloudy.
Whats the ammonia, nitrate and nitrite levels present in the tank?
If you have loads of ammonia present its definitely the fish waste produced due to the filter not being able to remove as much and more frequent changes are needed.
Nitrate means your filter isn't working properly. Make sure its the right size and larger for the aquarium if possible but not too much power that it bashes the fish.
Fin rot can be a by-product of open wounds. Have you seen your oscar doing some odd behavior, what ornaments are present in the tank? Plecos have been actually known to feed on fish, I haven't seen mine personally do it but if your pleco is it may be causing a little damage to the oscar.
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